How Alcohol Damages Your DNA

Article Source: Health And Fitness Journal

By Dr. Mercola

According to the Substance Abuse and Mental Health Services Administration, just over 26 percent of people over 18 reported binge drinking in the previous 30 days of the study when it was performed in 2015.1 Another 7 percent reported heavy alcohol use. This is congruent with the U.S. Surgeon General’s Report showing that substance abuse in the U.S. is skyrocketing, including alcohol abuse.2

According to the Centers for Disease Control and Prevention (CDC), alcohol poisoning kills six people every day.3 These are deaths related to short-term consumption of toxic amounts of alcohol that leads to central nervous system depression and shutdown in critical areas of the brain controlling breathing, heart rate and body temperature, ultimately resulting in death.4 This statistic does not address other negative effects alcohol has on your health.

In addition to being a central nervous system depressant, alcohol is a carbohydrate lacking in real nutritional value. Nearly one-third of Americans are obese and according to the CDC, in 2014 there was no state in the U.S. with a prevalence of obesity less than 20 percent.5

Although scientists have found associations between alcohol consumption and negative health conditions such as pancreatitis and stomach cancer, what has been missing is the precise nature in which alcohol damages your body. New research shows that as your body processes alcohol, a transient toxic compound is produced that attacks DNA.6

Alcohol Damages DNA and Increases Risk for Cancer

The research7 demonstrated the effect alcohol had on blood stem cells in mice. The researchers gave ethanol to mice and then used chromosome analysis and DNA sequencing to study genetic damage on the body by acetaldehyde, produced during the metabolic processing of alcohol.

The researchers from Cambridge University’s MRS Laboratory of Molecular Biology found a buildup of acetaldehyde happened when there is too much for the body to break down, or when mechanisms to reduce acetaldehyde function poorly.8

While previous research had pinpointed acetaldehyde as the culprit that caused DNA damage, those studies were performed on cell cultures and not on a living body. However, the evidence was strong enough to prompt the World Health Organization International Agency for Research on Cancer (IARC) to classify alcohol as a Group 1 carcinogen, their highest risk category.9 The researchers chose to study blood stem cells since they quickly replicate and readily spread genetic damage throughout the body.10 

Lead author Dr. Ketan Patel commented on the extent of the damage their data revealed, saying:11 “We saw huge amounts of DNA damage in these cells. Bits of DNA were deleted, bits were broken and we even saw parts of chromosomes being moved about and rearranged.”

The researchers found acetaldehyde breaks and damages DNA in blood cell stem cells, leading to rearranged chromosomes and permanently altering DNA sequences.12 This DNA damage increases your risk for seven types of cancer, including breast and bowel cancer. Patel explained:13

“Some cancers develop due to DNA damage in stem cells. While some damage occurs by chance, our findings suggest that drinking alcohol can increase the risk of this damage.”

The study also examined the body’s ability to protect itself from acetaldehyde and identified a family of enzymes that break the compound down into acetate, which your cells can use for energy. However, millions of people, especially those of Southeast Asian descent, either don’t have these enzymes, or the enzymes are faulty.14 This increases their risk of acetaldehyde accumulation, triggering greater DNA damage and a flushed face.

A second line of defense is a repair mechanism that helps repair DNA. However, Patel has found this doesn’t always work, and some individuals carry mutations in the mechanism.15 Data has revealed the number of deaths related to alcohol consumption and cancer has increased 62 percent in 12 years, rising from 3.6 percent in 2003 to 5.8 percent of deaths worldwide in 2015.16 Patel went on to say:17

“Our study highlights that not being able to process alcohol effectively can lead to an even higher risk of alcohol-related DNA damage and therefore certain cancers. But it’s important to remember that alcohol clearance and DNA repair systems are not perfect and alcohol can still cause cancer in different ways, even in people whose defense mechanisms are intact.”

Factors That Influence Your Tolerance to Alcohol

There are several ways alcohol may influence your risk of developing cancer. The American Cancer Society warns just a few drinks each week can increase your risk of breast cancer.18 The risk is higher in women who have low folate levels. Alcohol affects your hormones and an increased estrogen level triggered by alcohol is linked to breast cancer. Hormone levels are also affected in men, which can lead to infertility.19

Alcohol’s effect on your body is influenced by your body weight, ratio of muscle to fat, and how much and what kind of food you’ve recently eaten. Alcohol is one of the more addictive substances, and the National Council on Alcoholism and Drug Dependence estimates 1 in 12 Americans abuse alcohol or are dependent on the drug.20

Alcoholism is the third leading lifestyle-related cause of death in the U.S. and up to 40 percent of hospital beds are used to treat alcohol related conditions, with the exception of maternity and ICU beds.

Your pattern of consumption doesn’t appear to make a difference in the severity of your symptoms.21 Those who binge drink every week or two suffer some of the same conditions as those who drink daily. Dr. Alex Wodak, emeritus consultant at the Alcohol and Drug Service in Sydney Australia’s St. Vincent Hospital, describes the differences:22

“I’ve been in France early in morning and people, generally men, order a coffee and have a nip of brandy or whiskey, and they top up regularly during the day. They’re never intoxicated but there’s a formidable physical toll from all of that.

In the north of Europe, that kind of drinking style is very uncommon and what’s more common is for people to have two-thirds of a bottle of spirits once a week and they set fire to a soccer stadium or slash train seats or belt their wife up or someone in the street they don’t like the look of.”

Since alcohol is a carbohydrate, it not only damages your liver and raises levels of DNA-damaging acetaldehyde, but it also increases your risk of obesity. Health care costs tied to overconsumption of sugar account for at least one-third of health care costs spent each year in America.23 This equates to nearly $1 trillion each year. An increase in weight is linked to osteoarthritis, Type 2 diabetes, high blood pressure and gout, just to name a few.

Alcohol Affects More Than DNA

Alcohol triggers changes in more than your DNA, affecting nearly every cell and organ system in your body. In your brain, alcohol affects your limbic system that controls your emotions, which is why alcohol lowers your inhibitions. Your prefrontal cortex, a brain region associated with reasoning and judgment, also slows in response to alcohol, leading to more impulsive behavior and poor judgment. Chronically, in as little as one month, you may experience:24,25,26

  • Increased liver stiffness, which increases your risk of liver cirrhosis.
  • Diminished memory formation due to ethanol buildup in the brain. This is why you may not remember what you did while you were drunk. Alcohol also causes your hippocampus to shrink, which affects memory and learning.
  • Systemic inflammation. Alcohol significantly increases five inflammatory markers.27 Studies have shown even a single binge causes a dramatic rise in inflammation. In other words, your body reacts to alcohol in the same way as it reacts to injury or infection.
  • Increased stress on your heart, raising your risk for cardiomyopathy, arrhythmias, high blood pressure and stroke. Blood alcohol levels spike two to three hours after your last drink, which means it may occur in the middle of the night during sleep. This raises your risk of accidental death due to choking on your own vomit and/or suffering cardiac failure or stroke while sleeping.
  • Significantly increased endotoxin levels. Alcohol causes gut damage, allowing bacteria to escape from your gut into your bloodstream. Regular consumption also leads to elevated endotoxin levels,28 suggesting “sensible” drinking limits likely need to be much lower than the current 14 to 21 units current recommended in the U.K.29 How low is still unclear.

Less Is Always Better

Alcohol is a known cancer risk factor that contributes to cancer deaths. In research published by the American Cancer Society, scientists analyzed cancer diagnosis and death data compiled from the CDC and National Cancer Institute. They found 42 percent of cancer diagnoses and 45 percent of cancer deaths could be attributed to preventable or modifiable risk factors.30 Those factors included smoking, excess weight, alcohol intake, low consumption of fruits, vegetables, fiber and calcium, and lack of physical activity.

The researchers analyzed over 1.5 million cases of cancer and over 600,000 cancer deaths to evaluate whether a link existed between these modifiable factors and cancer. They found that lung and colorectal cancers had the highest number of diagnoses and deaths that could be attributed to preventable factors.31

Cigarette smoking was responsible for the greatest number of cases of cancer diagnosed, while obesity and being overweight was responsible for the second greatest number. Although alcohol related cancers ranked third on the list, alcohol is a contributing factor to obesity.

A combination of two of these modifiable factors, smoking and alcohol intake, are also related to the development of visible age-related signs.32 While most people are concerned with external appearance, it’s important to remember that damage done to your skin by these toxins is likewise being done to your internal cells and organ systems.

If you currently are a drinker, it is vital to consider how this impacts your overall health and increases your risk for several different health conditions. Research suggests that reducing or eliminating your alcohol intake and raising your exercise level will help reduce your risk of cardiovascular disease.

This makes sense when you consider the fact that exercise may be one of the most effective strategies for protecting and strengthening your heart, so much so that research shows regular exercise can significantly lower your health care costs if you have heart disease. According to one study, 30 minutes of vigorous exercise, five times per week, could result in annual health care savings of more than $2,500 per person.33

Exercise and Supplements May Reduce the Negative Effect on Your Body

Exercise is a foundational pillar to good health and may also help counteract inflammation in your body caused by alcohol.34,35 The data demonstrated those who got 2.5 hours of moderate activity a week reduced the biological impact of drinking, while those who got five hours or more of moderate activity experienced the same mortality as those who never drank.

Other research has demonstrated that long time drinkers who exercise regularly have less damage to white matter in their brains than those who exercise very little or not at all.36 Exercise may also reduce your risk of becoming dependent. Just like alcohol, exercise releases dopamine, a brain chemical associated with rewarding behaviors. Experiencing this feel good chemical may reduce your desire for alcohol and may help those who are dependent to lessen their cravings.37

Although this may help in the short run, alcohol impedes your desire for physical fitness and reduces your testosterone production, making it more difficult to build muscle. While I don’t recommend drinking, if you know you’ll be having a few drinks, using one of the following natural protocols prior to drinking may help minimize the damage to your body. However, this will not reduce your susceptibility to alcohol poisoning or other adverse events associated with binge drinking. So, please, use common sense and drink responsibly.

N-acetyl cysteine (NAC): NAC is a form of the amino acid cysteine. Many of its benefits relate back to the fact that it helps boost production of glutathione, an important antioxidant your body produces naturally that helps reduce free radical damage and plays a role in the detoxification of heavy metals and other harmful substances. It also reduces acetaldehyde toxicity that causes many hangover symptoms.38

Try taking NAC (at least 200 milligrams) 30 minutes before you drink to help lessen the alcohol’s toxic effects. NAC is both safe and inexpensive, and has been commercially available for a long time. It’s also generally well-tolerated and has no known serious side effects.

Consider that, like alcohol, one way that Tylenol causes damage to your liver is by depleting glutathione. If you keep your glutathione levels up, the damage from the acetaminophen may be largely preventable. This is why anyone who overdoses on Tylenol receives large doses of NAC in the emergency room — to increase glutathione.

B vitamins: NAC is thought to work even better when combined with vitamin B1 (thiamine).39 Vitamin B6 may also help to lessen hangover symptoms. Since alcohol depletes B vitamin in your body, and B vitamins are required to help eliminate alcohol from your body, a B-vitamin supplement taken beforehand, as well as the next day, may help.

Milk thistle: Milk thistle contains silymarin and silybin, antioxidants known to help protect your liver from toxins, including the effects of alcohol. Not only has silymarin been found to increase glutathione, but it also may help to regenerate liver cells.40 A milk thistle supplement may be most useful when taken regularly, especially if you know you’ll be having cocktails on more than one occasion.

Vitamin C: Alcohol may deplete your body of vitamin C, which is important for reducing alcohol-induced oxidative stress in your liver. Interestingly, one animal study showed vitamin C was even more protective to the liver than silymarin (milk thistle) after exposure to alcohol.41

Making sure you’re getting enough vitamin C, either via supplements or food, is another trick to use prior to indulging in alcoholic beverages. Vitamin C is actually such a powerful detoxifier that if you take large doses prior to receiving dental anesthesia, the anesthesia will be significantly weakened and may not work.

Magnesium: Magnesium is another nutrient depleted by alcohol, and it’s one that many are already deficient in.42 Plus, magnesium has anti-inflammatory properties that may help to reduce some hangover symptoms. If you don’t eat a lot of magnesium-rich foods, taking a magnesium supplement before an evening involving drinking may be helpful.

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Weekly Health Quiz: Apple Cider Vinegar, Mitochondria and Lectins

Article Source: Health And Fitness Journal

1 Apple cider vinegar is made through what type of process that renders it rich in bioactive components like acetic acid, giving it potent antioxidant, antimicrobial and many other beneficial properties?

  • Digestion
  • Fermentation

    Apple cider vinegar is made through a fermentation process that renders it rich in bioactive components like acetic acid, giving it potent antioxidant, antimicrobial and many other beneficial properties. Learn more.

  • Distillation
  • Nuclear fragmentation

2 The most important metabolic intervention radically improving mitochondrial regeneration and stem cell production is:

  • Exercise, especially strength training
  • Intermittent Fasting
  • Multiday water fasting

    Multiday water fasting is an effective antiaging strategy that activates your body’s ability to promote cellular protection, regeneration and rejuvenation. Learn more.

  • Lowering EMF exposure

3 Seventy to 80 percent of your immune system resides in your:

  • Brain
  • Gut

    Because 70 to 80 percent of your immune system resides within your gastrointestinal tract, optimizing your gut microbiome can have far-reaching effects on your physical health and emotional well-being. Learn more.

  • Lymphatics
  • Cerebrospinal fluid

4 A type of meditation in which you focus on paying attention to the moment you’re in right now is called:

  • Cognitive skills meditation
  • Emotional freedom technique
  • Mindfulness meditation

    One type of meditation easily applied to virtually any activity is called “mindfulness,” which involves paying attention to the moment you’re in right now. Learn more.

  • Transcendental meditation

5 What substance released during exercise can improve your mitochondrial health, slow down age-related muscle decline and boost your heart and brain health?

  • Ketones
  • Nitric oxide

    The Nitric Oxide Dump workout stimulates your body’s release of nitric oxide, improving your mitochondrial health, slowing down age-related muscle decline and boosting heart health. Learn more.

  • cAMP (cyclic AMP)
  • PGC 1-alpha

6 Popular commercial cleaners contain chemicals that may damage your:

  • Liver
  • Kidneys
  • Central nervous system
  • All of the above

    Commercial cleaners emit toxic chemicals that may cause organ damage and cancer. Clean your home safely and effectively using natural ingredients like baking soda, vinegar, coconut oil, lemons and castile soap. Learn more.

7 Among the most problematic lectin-containing foods are beans, grains, legumes and members of the nightshade family like eggplants, potatoes and peppers. The best way to reduce lectins in cooked beans is by:

  • Soaking them for at least eight hours before cooking
  • Using a pressure cooker

    The best way to neutralize lectins when cooked is in a pressure cooker. Learn more.

  • Sprouting them
  • Cooking them in a slow cooker


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Ghost in the Machine, Part 4 — The War on Supplements, Essential Oils and Homeopathy

Article Source: Health And Fitness Journal

By Dr. Mercola

If you suspect that supplements are more popular than ever, you are right. More than half of American adults have used one or more supplements and more than half of women and 43 percent of men used a supplement of some kind within the last 30 days.1,2

While that means not taking vitamins or supplements is now a minority position, it also means Big Pharma is trying to get “in on” the supplement business. The U.S. retail sales of vitamins and supplements is expected to exceed $36 billion in 2017.3 While that’s less than a tenth of what Pharma rakes in annually, it has nevertheless caught the drug industry’s attention.

Also, the highest users of supplements and alternative therapies are the most desirable demographic to marketers — those reporting “excellent” or “very good” health, usually with a higher discretionary income.4 No wonder Pharma and Pharma-supported voices have launched an all-out smear campaign against supplements and alternative therapies. Both categories lack the huge price tags of drugs and encourage patient education and self-care.

Supplements and natural products also often treat or prevent the very conditions that enrich drug companies, which further explains Big Pharma’s wrath. For example, probiotic-rich fermented food treats the heartburn for which Pharma hawks dangerous proton pump inhibitors (PPIs). Omega-3 fats such as krill oil and other nonprescription products lower heart disease risks without using dangerous statins.

Prescription drugs can also increase the need for supplements. If you take a diuretic, an acid-blocking PPI or the diabetes drug metformin, you are more likely to develop vitamin or mineral deficiencies.5

Traditional Media Outlets Question Value of Supplements

In 2016, the Journal of the American Medical Association published a large study of U.S. supplement usage that found, according to The New York Times:6

“Americans spend more than $30 billion a year on dietary supplements — vitamins, minerals and herbal products, among others — many of which are unnecessary or of doubtful benefit to those taking them. That comes to about $100 a year for every man, woman and child for substances that are often of questionable value.”

Elsewhere in recent years, negative news articles about vitamin C, vitamin A and beta carotene, vitamin E, vitamin B6, vitamin D, calcium and multivitamins have run. Supplements like ginkgo biloba, echinacea, fish oil and ephedrine are also under attack, as are homeopathy and aromatherapy.7,8,9,10

Some articles, many written by medical professionals, say supplements are ineffective and a waste of your money; others actually accuse supplements of causing or risking physical harm and even shortening lives. Some medical specialists also accuse supplements of impeding or interfering with drugs taken for other medical conditions.11

In addition to print media and the web, TV news media have joined in the discrediting of the supplement industry, exposing alleged disreputable manufacturers and lobbyists.

While I would never defend unethical makers of supplements who put the public at risk, these same news shows largely give Big Pharma a pass even though prescription drugs put the public at a much greater risk. Prescription drug overdoses are the ninth leading cause of death in the U.S., and the death toll continues to rise thanks to the growing opioid addiction crisis.12

Pharma Is a Pot Calling the Kettle Black

Leading Pharma’s campaign to discredit supplements is the charge that unproven health benefits, not backed by the U.S. Food and Drug Administration (FDA), are claimed by supplement makers. Yet almost every major drug company has entered into a settlement for the same thing, known as “off-label marketing” in the prescription drug world. At least 31 drug companies have been charged with such false promotion including Pfizer, Eli Lilly, Johnson & Johnson, Novartis, Forest, Amgen and Allergan.13

Pfizer paid a $430 million fine for off-label marketing of Neurontin for the non-FDA approved indication of bipolar disorder.14 Eli Lilly engaged in another off-label marketing scheme, trying to market the selective estrogen receptor modulator Evista for the unapproved FDA indication of prevention of breast cancer, and unleashed hundreds of drug reps to sell the unapproved use.

Reps were told to hide a disclosure page that said, “The effectiveness of [Evista] in reducing the risk of breast cancer has not yet been established,” from the doctors they were trying to sell on the drug, according to the Department of Justice.15 Scott Gottlieb, the new FDA Commissioner, drug stock trader and Pharma consultant, defended Evista’s off-label marketing in a Wall Street Journal oped.16

Questions About Product Purity Cut Both Ways

Another way that Pharma-friendly voices try to discredit supplements they have yet to sell themselves is through raising questions about their purity, label accuracy and manufacturing process. Here is a quote from Dr. Paul A. Offit, one of the nation’s leading drug and vaccine defenders, in an interview about his 2014 book “Do You Believe in Magic?” on Medscape:17

“Look at what happened with this vitamin-maker called Purity First. Purity First, a few weeks ago, had all of its products recalled by the FDA. They made three products. They made vitamin C. They made a multimineral preparation, and they made a B-complex vitamin preparation.

What happened was there were 25 women in Connecticut who started to develop symptoms of increased hair where they didn’t want hair to be, deepening of the voice, and loss of menstrual cycles because they were inadvertently taking anabolic steroids.

Anabolic steroids had contaminated those preparations. How does that happen?… Just imagine if vaccines were inadvertently contaminated with anabolic steroids. You would never hear the end of it, but here somehow it all gets a free pass.”

Offit is dead wrong. Drugs, vaccines and medical products are frequently recalled for quality and contamination though recalls are seldom reported in the mainstream press. In April 2017, GlaxoSmithKline recalled nearly 600,000 defective Ventolin inhalers.18 In March 2017, generic giant Mylan (of EpiPen fame) said it was recalling 4,005,177 bottles of the cholesterol fighter atorvastatin because of the “potential of an elevated bioburden with identification of objectionable organisms.”19

Recalls of biologics (drugs that contain an ingredient extracted from a “biological” source such as cells from humans, animals or microorganisms) have increased significantly, especially for vaccines. From 2007 to 2010, 14 vaccine recalls and 13 recalls for immunoglobulins were made. Additionally, vaccines are not adequately tested for safety and effectiveness using methodologically sound scientific studies before they are licensed, so all of their side effects and long-term negative health outcomes are often unknown.

Examples of Supplements, Essential Oils and Homeopathy Therapy at Work

The medical literature includes notable examples of supplements and natural remedies that function as valuable medicines. Why do we so rarely, if ever, hear of them on health news sites or TV? Supplements and natural substances cannot be patented and hence present no profit potential for Pharma no matter how dramatic their actions. Here are some supplements for which there is promising evidence of effectiveness:

Folic acid, when added to enalapril (an ACE inhibitor used to treat high blood pressure, diabetic kidney disease and heart failure) produced a significant reduction in stroke occurrence in 2015 JAMA research.20

Oregano might be effective against the norovirus, say investigators at the University of Arizona.21

High doses of vitamin C may be useful in the treatment of ovarian cancer, boost the power of chemotherapy and ward off stroke, research indicates.22,23,24

Multivitamins and olive oil are under investigation for their roles in managing breast cancer.25,26

A compound found in a Japanese mushroom could be a cure for the currently untreatable human papilloma virus.27

Vitamin E likely plays an important role in deterring miscarriage.28

Preliminary evidence even suggests that micronutrients could be beneficial in treating adult attention deficit hyperactivity disorder (ADHD), according to 2014 research published in The British Journal of Psychiatry.29

When children with ADHD inhaled vetiver essential oil three times a day for 30 days they had improved brain wave patterns and behavior and did better in school.

In patients with allergies, those using homeopathy reported improvements in nasal airflow compared with a placebo group and researchers described a “clear, significant and clinically relevant improvement in nasal inspiratory peak flow, similar to that found with topical steroids.”

Don’t Rule Out Vitamin D

In the past few years, vitamin D has gone from a vitamin “hero” whose deficiency potentially explained many maladies, to VNG (Vitamin Non Grata).30,31 The same flip-flop has been seen with calcium, once a good guy, now potentially another supplemental bad guy.32 In fact, vitamin D has been so demonized, the pro-Pharma Forbes site actually writes:33

“Vitamin D supplements, to put it plainly, are a waste of money. (For those concerned about osteoporosis, the widely used drug alendronate (Fosamax®), has been shown to increase bone density by about 5 percent, as explained in a 2011 article by Dr. Sundeep Khosia. But Fosamax has side effects.)”

The “side effects” mentioned by Forbes are an understatement. Bisphosphonate bone drugs such as Fosamax and Boniva have been linked to esophageal cancer, jawbone death, heart problems, intractable pain and the very fractures they are supposed to prevent.34 They are one of the most dangerous drug classes ever marketed.

Far from a waste of money, vitamin D made such a difference in a 2014 breast cancer survival study, an investigator said “There is no compelling reason to wait for further studies to incorporate vitamin D supplements into standard care regimens.”35 Research suggests it may have a valuable role in multiple sclerosis management, diabetes and depression, chronic liver disease and diseases of older age.36,37,38,39

Final Ironies

Even as the drug industry attacks the safety, reliability and effectiveness of vitamins and supplements, it creates them itself. In 2013, PGT Healthcare LLP (a venture of Procter & Gamble, Teva and Swisse Wellness) said it would expand its range of more than 100 vitamins, minerals and supplements.40

Other drug giants are also in the supplement business. Sometimes making vitamins results in drug companies making positive instead of negative statements. Here is what research funded by Roche (now DSM Nutritional Products) BASF and Pfizer found about multivitamins41

“A daily multivitamin can help a man reduce his risk of cancer, according to new research from Brigham and Women’s Hospital (BWH). The first-of-its kind study will be presented October 17 at the 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research and published online the same day in the Journal of the American Medical Association.”

Marketing vitamins also subjects Big Pharma to the same false claims charges it cites about the supplement industry. Pfizer, which makes Centrum products, was sued to remove its claims that the products support “energy and immunity,” “heart health,” “eye health,” “breast health,” “bone health” and “colon health.”42 And although Merck announced December 14 that it plans to sell its subsidiary, Seven Seas, a quick look at its Seven Seas Multivitamin Complete reveals claims that it contains ingredients that “provide adults with energy … as well as a healthy heart … good eye sight, healthy bones and digestion system.”43

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